Third mRNA COVID-19 vaccine dose appears to be safe

Third mRNA COVID-19 vaccine dose appears to be safe


The third dose of the COVID-19 mRNA vaccine is safe, according to a study published online April 14 in JAMA Network Open.

Michiel J.M. Niesen, Ph.D., from nference in Cambridge, Massachusetts, and colleagues evaluated the safety of vaccination with U.S. Food and Drug Administration–approved COVID-19 mRNA vaccines. Electronic health record data (December 2020 to October 2021) were used to identify 47,999 individuals receiving three-dose COVID-19 mRNA vaccines.

The researchers found that reporting of severe adverse events remained low after the third vaccine dose, with rates of pericarditis (0.01 percent), anaphylaxis (0 percent), myocarditis (0 percent), and cerebral venous sinus thrombosis (no individuals) consistent with results from earlier studies. Compared to the second dose, significantly more individuals reported low-severity adverse events after the third dose, including fatigue, lymphadenopathy, nausea, headache, arthralgia, myalgia, diarrhea, fever, vomiting, and chills.

“This study provides further evidence suggesting that third-dose vaccination with the same type of COVID-19 mRNA as used in the primary series is associated with safe outcomes in eligible populations,” the authors write. “Together with previous studies of the safety and effectiveness associated with booster doses, our study suggests that third-dose mRNA COVID-19 vaccination may be appropriate for at-risk populations.”

Two authors disclosed financial ties to , including Pfizer and Moderna.


Third mRNA vaccine dose ups effectiveness against hospitalization


More information:
Michiel J. M. Niesen et al, Surveillance of Safety of 3 Doses of COVID-19 mRNA Vaccination Using Electronic Health Records, JAMA Network Open (2022). DOI: 10.1001/jamanetworkopen.2022.7038

© 2022 HealthDay. All rights reserved.

Citation:
Third mRNA COVID-19 vaccine dose appears to be safe (2022, April 15)
retrieved 15 April 2022
from https://medicalxpress.com/news/2022-04-mrna-covid-vaccine-dose-safe.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.



Source link

Leave a Reply